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Developments in cancer prevention and treatment using traditional Chinese medicine

Hongsheng Lin, Jie Liu, Ying Zhang

Frontiers of Medicine 2011, Volume 5, Issue 2,   Pages 127-133 doi: 10.1007/s11684-011-0137-7

Abstract: traditional Chinese medicine (TCM) and integrated medicine of oncology, we have made some achievements in cancertreatment using TCM in over 50 years, including treatment concepts, methods, and basic and clinicalCurrently, TCM plays an indispensable role in cancer prevention and treatment.In the future, cancer treated with TCM will face unprecedented opportunities and challenges.This article reviews the developments of TCM in the treatment of cancer.

Keywords： traditional Chinese medicine (TCM)     cancer    

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Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 18-42 doi: 10.1007/s11684-022-0976-4

Abstract: With the improved understanding of driver mutations in non-small cell lung cancer (NSCLC), expandingFinally, we listed the emerging treatment strategies for the new oncogenic alternations, and proposed

Keywords： non-small cell lung cancer     driver mutations     treatment strategy     resistant mechanism     immune-checkpoint    

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Plasma for cancer treatment: How can RONS penetrate through the cell membrane?

Annemie Bogaerts, Maksudbek Yusupov, Jamoliddin Razzokov, Jonas Van der Paal

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 2,   Pages 253-263 doi: 10.1007/s11705-018-1786-8

Abstract: Plasma is gaining increasing interest for cancer treatment, but the underlying mechanisms are not yetBoth mechanisms may explain the selective cytotoxic effect of plasma towards cancer cells.

Keywords： plasma medicine     cancer treatment     computer modelling     cell membrane     reactive oxygen and nitrogen species    

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Molecular classification of non-small-cell lung cancer: diagnosis, individualized treatment, and prognosis

Yue Yu, Jie He

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 157-171 doi: 10.1007/s11684-013-0272-4

Abstract:

Non-small-cell lung cancer (NSCLC) is the most common cause of premature death among the malignantprognosis of NSCLC based on an improved molecular classification scheme may promote individualized treatmentreported during the past decade, as well as their applications for improving the diagnosis, staging and treatment

Keywords： non-small-cell lung cancer     molecular typing     individualized medicine     molecular-targeted therapy     gene expression    

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Glyco-functionalised quantum dots and their progress in cancer diagnosis and treatment

Jayshree Ashree, Qi Wang, Yimin Chao

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 3,   Pages 365-377 doi: 10.1007/s11705-019-1863-7

Abstract: breakthroughs in recent years of research, we are still unsuccessful to effectively diagnose and treat cancerThus, the development of a novel approach for cancer detection and treatment is crucial.lectins, Glyco-functionalised QD is a new prospect in constructing biomedical imaging platform for cancerbehaviour study as well as treatment.utilisation of Glyco-functionalised QDs as well as their future prospective to interpret and confront cancer

Keywords： carbohydrate     leptin     glyco-functionalised QD     bioimaging     cancer diagnosis and treatment    

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Complex interplay between tumor microenvironment and cancer therapy

Minhong Shen, Yibin Kang

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 426-439 doi: 10.1007/s11684-018-0663-7

Abstract: The TME is highly dynamic and its importance in different stages of cancer progression has been wellA growing body of evidence suggests that TME also plays pivotal roles in cancer treatment responses.TME is significantly remodeled upon cancer therapies, and such change either enhances the responses orprovide an overview of the essential components in TME and the remodeling of TME in response to anti-cancer

Keywords： tumor microenvironment     therapy response     treatment resistance    

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Human microbiome and prostate cancer development: current insights into the prevention and treatment

Solmaz Ohadian Moghadam, Seyed Ali Momeni

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 11-32 doi: 10.1007/s11684-019-0731-7

Abstract: The human microbiome may influence prostate cancer development.Current studies suggest that the microbiota of men with prostate cancer significantly differs from thatas altered responses to treatment.Furthermore, we discuss strategies to target the microbiome for risk assessment, prevention, and treatmentof prostate cancer.

Keywords： microbiome     prostate cancer     prevention     treatment     molecular pathological epidemiology (MPE)     biomarker    

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Clinical outcomes and prognostic factors of patients with epithelial ovarian cancer subjected to first-linetreatment: a retrospective study of 251 cases

Yunfeng Fu, Xinyu Wang, Zimin Pan, Xing Xie

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 91-95 doi: 10.1007/s11684-014-0305-7

Abstract:

A total of 251 patients with epithelial ovarian cancer (EOC) treated between 2002 and 2008 was retrospectivelyThe median follow-up period from the end of initial treatment to June 2010 was 58 months.

Keywords： ovarian carcinoma     prognostic factors     surgery     chemotherapy     survival    

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Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-likecells enriched with tumor spheroids from a non-small cell lung cancer cell line

Douglas D. Fang, Joan Cao, Jitesh P. Jani, Konstantinos Tsaparikos, Alessandra Blasina, Jill Kornmann, Maruja E. Lira, Jianying Wang, Zuzana Jirout, Justin Bingham, Zhou Zhu, Yin Gu, Gerrit Los, Zdenek Hostomsky, Todd VanArsdale

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 462-476 doi: 10.1007/s11684-013-0270-6

Abstract: become crucial for developing more effective therapies that target highly tumorigenic and drug-resistant cancerIn this study, we demonstrate that a subset of cancer cells with CSC properties may be enriched intotumor spheroids under stem cell conditions from a non-small cell lung cancer cell line.

Keywords： drug resistance     cancer stem cell     checkpoint kinase 1 (CHK1)     PF-00477736     lung cancer     tumorigenicity    

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Patient-derived xenograft platform of OSCC: a renewable human bio-bank for preclinical cancer researchand a new co-clinical model for treatment optimization

Shuyang Sun,Zhiyuan Zhang

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 104-110 doi: 10.1007/s11684-016-0432-4

Abstract: next-generation sequencing and bioinformatics have begun to reveal the complex genetic landscape in human cancerrepresent intra- and inter-tumoral heterogeneity are required to understand the molecular diversity of cancerfeatures of their donor tumors have been shown to be the preferred preclinical tool in translational cancersuccessfully established and characterized an OSCC PDX panel as part of our tumor bio-bank for translational cancerthis well-annotated PDX panel in the development of co-clinical trials for patient stratification and treatment

Keywords： patient-derived xenograft models     personalized medicine     co-clinical trial     patient stratification     oral squamous cell carcinoma    

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Production of pectic extracts from sugar beet pulp with antiproliferative activity on a breast cancer

Jacqueline CONCHA, Caroline WEINSTEIN, María Elvira Zú?IGA

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 4,   Pages 482-489 doi: 10.1007/s11705-013-1342-5

Abstract: which depends on the extraction method, is decisive in their capacity to induce apoptosis on several cancerlipid extraction with hexane, removal of soluble complex carbohydrates and proteins, and enzymatic treatmentThe enzymatic treatment was carried out with Rohapect DA6L under the following conditions: 50°C, pH 4.0The pectic extract was examined for its antiproliferative activity on the MCF-7 breast cancer cell line

Keywords： pectic extracts     antiproliferative activity     breast cancer     enzymatic treatment    

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Immunotherapy-based combination strategies for treatment of gastrointestinal cancers: current status

Chenfei Zhou, Jun Zhang

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 12-23 doi: 10.1007/s11684-019-0685-9

Abstract:

Strategies in comprehensive therapy for gastrointestinal (GI) cancer have been optimized in the lastHowever, treatment options remain limited for late-stage or refractory diseases.The efficacy of immune checkpoint inhibitors (ICIs) for treatment of refractory GI cancer has been confirmedIn 2017, pembrolizumab was approved by the US Food and Drug Administration as the first agent for treatmentof GI cancer.

Keywords： gastrointestinal cancer     immune checkpoint inhibitor     combination therapy    

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Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 942-942 doi: 10.1007/s11684-021-0876-z

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Progress and challenges in RET-targeted cancer therapy

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 207-219 doi: 10.1007/s11684-023-0985-y

Abstract: Oncogenic RET fusions or mutations are found most often in non-small cell lung cancer (NSCLC) and inthyroid cancer, but also increasingly in various types of cancers at low rates.TKI-tolerated persisters to identify a converging point of vulnerability to devise an effective co-treatment

Keywords： pralsetinib     selpercatinib     RET-alteration     lung cancer     thyroid cancer     tumor-agnostic therapy     drug    

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Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Yun Zhang, Robert A. Weinberg

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 361-373 doi: 10.1007/s11684-018-0656-6

Abstract: termed the epithelial-to-mesenchymal transition (EMT) plays an important role in both development and cancerinvasiveness, drug-resistance and the ability to form metastases at distant organs, and thereby contribute to cancer

Keywords： epithelial-to-mesenchymal transition     cancer     metastasis     cancer stem cell    

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Title Author Date Type Operation

Developments in cancer prevention and treatment using traditional Chinese medicine

Hongsheng Lin, Jie Liu, Ying Zhang

Journal Article

Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future

Journal Article

Plasma for cancer treatment: How can RONS penetrate through the cell membrane?

Annemie Bogaerts, Maksudbek Yusupov, Jamoliddin Razzokov, Jonas Van der Paal

Journal Article

Molecular classification of non-small-cell lung cancer: diagnosis, individualized treatment, and prognosis

Yue Yu, Jie He

Journal Article

Glyco-functionalised quantum dots and their progress in cancer diagnosis and treatment

Jayshree Ashree, Qi Wang, Yimin Chao

Journal Article

Complex interplay between tumor microenvironment and cancer therapy

Minhong Shen, Yibin Kang

Journal Article

Human microbiome and prostate cancer development: current insights into the prevention and treatment

Solmaz Ohadian Moghadam, Seyed Ali Momeni

Journal Article

Clinical outcomes and prognostic factors of patients with epithelial ovarian cancer subjected to first-linetreatment: a retrospective study of 251 cases

Yunfeng Fu, Xinyu Wang, Zimin Pan, Xing Xie

Journal Article

Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-likecells enriched with tumor spheroids from a non-small cell lung cancer cell line

Douglas D. Fang, Joan Cao, Jitesh P. Jani, Konstantinos Tsaparikos, Alessandra Blasina, Jill Kornmann, Maruja E. Lira, Jianying Wang, Zuzana Jirout, Justin Bingham, Zhou Zhu, Yin Gu, Gerrit Los, Zdenek Hostomsky, Todd VanArsdale

Journal Article

Patient-derived xenograft platform of OSCC: a renewable human bio-bank for preclinical cancer researchand a new co-clinical model for treatment optimization

Shuyang Sun,Zhiyuan Zhang

Journal Article

Production of pectic extracts from sugar beet pulp with antiproliferative activity on a breast cancer

Jacqueline CONCHA, Caroline WEINSTEIN, María Elvira Zú?IGA

Journal Article

Immunotherapy-based combination strategies for treatment of gastrointestinal cancers: current status

Chenfei Zhou, Jun Zhang

Journal Article

Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer

Journal Article

Progress and challenges in RET-targeted cancer therapy

Journal Article

Epithelial-to-mesenchymal transition in cancer: complexity and opportunities

Yun Zhang, Robert A. Weinberg

Journal Article